Publication
We regularly publish publications to inform the scientific community of discoveries from HKCeND team.
Using blood transcriptome analysis for Alzheimer’s disease diagnosis and patient stratification
Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T. W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C. F. Ip, John Hardy, Amy K. Y. Fu, Nancy Y. Ip
Alzheimers Dement. 7 Feb 2024
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer’s disease across ethnic groups
Jiang Y., Uhm H, Ip F.C.F., Ouyang L., Lo RMN, Cheng E.Y.L., Cao X., Tan C.M.C., Law B.C.H., Ortiz-Romero P., Puig-Pijoan A., Fernández-Lebrero A., Contador J., Mok K.Y., Hardy J., Kwok T.C.Y., Mok V.C.T., Suárez-Calvet M., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 6 Jan 2024
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
Lau S.F., Wu W., Wong H.Y., Ouyang L., Qiao Y., Xu J., Lau H.Y.J., Wong C., Jiang Y., Holtzman D.M., Fu A.K.Y. and Ip N.Y.
Nature Aging 21 Sep 2023
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen J., Ye T., Chen Y., Zhang Y., Ma S., Lo M.N.R., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Guo Q., Mok K.Y., Shoai M., Hardy J., Chen L., Fu A.K.Y. and Ip N.Y.
Commun Med (Lond) 6 Apr 2023
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
Jiang Y., Zhou X., Wong H.Y., Ouyang L., Ip F.C.F., Chau M.N.V., Lau S.F., Wu W., Wong Y.K.D., Seo H., Fu W.Y., Lai C.H.N., Chen Y., Chen Y., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Mok C.Y.T., Shoai M., Lehallier B., Losada P.M., O’Brien E., Porter T., Laws S.M., Hardy J., Wyss-Coray T., Masters C.L., Fu A.K.Y. and Ip N.Y.
Nature Aging 2 Jul 2022
Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong
Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y.
J Alzheimers Dis. 16 Apr 2022
Deep learning for polygenic score analysis for Alzheimer’s disease risk prediction in the Chinese population
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 3 Dec 2021
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Duan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y.
Nat Biomed Eng. 26 Jul 2021
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer’s disease screening and staging
Jiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 25 May 2021
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
Ye T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y.
Communications Biology 2 Feb 2021
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
STAR Protocols 19 Jan 2021
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Wang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 5 Jan 2021
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
Lau S.F., Cao H., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 28 Sep 2020
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