Investigating Therapeutic Targets and Pathways in Alzheimer’s Disease Using Patient-Based Modelling Approaches

Elucidation of pathological mechanisms of Alzheimer’s disease (AD) and identification of candidates for drug discovery are the aim of this program. Given the lack of studies into molecular mechanisms underlying AD in non-Caucasian populations, the HKCeND research team has established iPSC repositories for the Chinese population. Novel drug discovery platforms utilizing iPSC-derived human cell system will be developed to identify AD-associated targets and evaluate the effects of potential drug candidates on AD patients, paving the way to new therapeutics development for AD.